The Baptist Campus Ministries (BCM) is a Christian fellowship and service organization open to students of all denominations who are looking for an opportunity to get to know other Christian students. Weekly meetings, Bible studies, fellowships, state conventions, retreats, mission trips, and other activities provide opportunities for fun and spiritual growth. All students who are interested in growing spiritually and in making new friends are welcome.

The Concert Choir is traditional choral group open to students and community members. The repertoire consists of music from many styles and genres. The Concert Choir presents several concerts throughout the year.

The Diamond Dolls is a group consisting of all females who enjoy baseball and want to help the baseball team. The mission of the organization is to help promote baseball on campus and to encourage team spirit. Activities include selling concessions at home games, providing snacks for away games, and field beautification. Monthly meetings are held and interviews are required to join.

The Entertainers is an auditioned group of singers and instrumentalists whose main purpose is to serve as ambassadors to the College and provide musical entertainment for area schools, civic and state organizations, military functions and community activities. The group features an upbeat show with repertoire from many styles and genres, including show tunes, ballads, pop, jazz, and patriotic selections. Many selections are complemented with choreography and other staging. The Entertainers presents many concerts throughout the year.

The ESCC Band is a traditional instrumental ensemble open to students and community members. The repertoire consists of music from many styles and genres. The ESCC Band presents several concerts throughout the year.

The ESCC History Club is a student organization made up of students who are interested in the study of history.  The club conducts  a variety of activities to promote knowledge of the past and appreciation for history.  Membership is open to any current Enterprise State Community College student.

The ESCC Players is a group of students and community members whose main purpose is to promote the art of theatre production and stage performance, with dramatic works ranging from one-act plays to Broadway musicals. The ESCC Players presents two or more theatrical productions each year.

The First Impressions Team (FIT) is a select organization of student orientation leaders who participate in all ESCC orientations. FIT acts as student guides, directs get-acquainted activities, assists advisors in scheduling, and presents several orientation workshops. This group of students are positive, out-going, and enjoy helping ESCC freshmen make the transition to college life. Students with a 2.5 GPA compete for FIT selection in an application, role-playing, and interview process.

The Interclub Council is a branch organization of the Student Government Association. It was organized in the fall of 1968 with the purpose of aiding the SGA in coordinating club activities. The Interclub Council promotes communication among campus organizations and coordinates projects of mutual benefit and interest. Membership in the Interclub Council consists of one representative chosen by each campus organization. The SGA vice president serves as president of the Council and other officers are selected by the Council.

The Enterprise State Community College Ambassadors serve as the official hosts and hostesses for the College. These students act as tour guides for visiting groups and also help with events on campus such as English and Math Tournaments and Scholars Bowl. In order to be selected as a Mentor, students must be enrolled full-time, have a 2.5 GPA, complete an application and participate in an interview.

The Tau Mu chapter of the Phi Theta Kappa, a national scholastic honorary fraternity for two-year colleges, was chartered in March, 1969. The purposes of the organization are to offer a means by which the students who achieve academic excellence may be recognized and to encourage academic excellence among the students at Enterprise State Community College.

The main purpose of the Spirit Club is to promote and support College athletic events. The club also performs service activities for the College. Membership is open to all ESCC students.

The Student Government Association (SGA) is composed of four officers, seven sophomore senators, and seven freshman senators. All members of the Student Government Association are elected by the student body. The purposes of the SGA are to provide liaison between students and the faculty and administration, to promote social and cultural opportunities for students, and to approve and charter all organizations which function on the campus.